Atazanavir-d6

An internal standard for the quantification of atazanavir

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1mg

￥4075.00

3260.00

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货号: ajcx21734
CAS: 1092540-50-5
别名: 阿扎那韦D6,BMS-232632-d6
分子式: C38H46D6N6O7
分子量: 710.9
纯度: >98%
溶解度: Ethanol: Slightly Soluble,Methanol: Slightly Soluble
储存: Store at -20°C
库存: 现货

Background

Atazanavir-d₆ is intended for use as an internal standard for the quantification of atazanavir by GC- or LC-MS. Atazanavir is an azapeptide inhibitor of HIV-1 protease (K_i = 2.66 nM).¹ It has antiviral activity against a variety of HIV-1 strains in several cell types with EC₅₀ values ranging from 2.62 to 5.28 nM. Atazanavir exhibits a minor synergistic effect when used in combination with the reverse transcriptase inhibitor zidovudine in HIV-1-infected human peripheral blood mononuclear cells (PBMCs) and an additive effect when used in combination with several additional reverse transcriptase or HIV-1 protease inhibitors. Atazanavir also inhibits UDP-glucuronyltransferase 1A1 (UGT1A1), which is involved in bilirubin clearance.² Formulations containing atazanavir have been used in combination therapy for the treatment of HIV-1 infection.

1.Robinson, B.S., Riccardi, K.A., Gong, Y.F., et al.BMS-232632, a highly potent human immunodeficiency virus protease inhibitor that can be used in combination with other available antiretroviral agentsAntimicrobial Agents and Chemotherapy44(8)2093-2099(2000) 2.Michaud, V., Bar-Magen, T., Turgeon, J., et al.The dual role of pharmacogenetics in HIV treatment: Mutations and polymorphisms regulating antiretroviral drug resistance and dispositionPharmacological Reviews64(3)803-833(2012)