AZ9482
A PARP inhibitor
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
-
包装价格促销价数量
-
1mg￥737.00590.00- +
-
5mg￥1975.001580.00- +
-
10mg￥3212.002570.00- +
-
25mg￥6100.004880.00- +
已选
0
种
0
瓶
金额:
￥0.00
首页
收藏
- 货号: ajcx21760
- CAS: 1825345-33-2
- 别名:
- 分子式: C26H22N6O2
- 分子量: 450.5
- 纯度: ＞98%
- 溶解度: DMF: 0.25mg/mL,DMSO: 0.15mg/mL
- 储存: Store at -20°C
- 库存: 现货
Background
AZ9482 is a poly(ADP-ribose) polymerase (PARP) inhibitor (IC50s = 1, 1, 46, 640, 9, and 160 nM for PARP1, -2, -3, -6, TNKS1/PARP5a, and TNKS2, respectively).1 It induces centrosome declustering (EC50 = <18 nM) and a multipolar spindle phenotype in HeLa cells. AZ9482 inhibits the growth of OCI-LY19 diffuse large B cell lymphoma (DLBCL) cells (GI50 = 3 nM).
1.Johannes, J.W., Almeida, L., Daly, K., et al.Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clusteringBioorg. Med. Chem. Lett.25(24)5743-5747(2015)
