BE-24566B

A fungal metabolite

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库存: 现货

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1mg

￥5650.00

4520.00

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货号: ajcx21774
CAS: 149466-04-6
别名: L-755,805
分子式: C27H24O7
分子量: 460.5
纯度: >98%
溶解度: Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
储存: Store at -20°C
库存: 现货

Background

BE-24566B is a polyketide fungal metabolite originally isolated from S. violaceusniger.¹ It is active against B. subtilis, B. cereus, S. aureus, M. luteus, E. faecalis, and S. thermophilus (MICs = 1.56, 1.56, 1.56, 1.56, 3.13, and 3.13 µg/ml, respectively). BE-24566B is an endothelin (ET) receptor antagonist (IC₅₀s = 11 and 3.9 µM for ET_A and ET_B receptors, respectively).²

1.Kojiri, K., Nakajima, S., Fuse, A., et al.BE-24566B, a new antibiotic produced by Streptomyces violaceusnigerJ. Antibiot. (Tokyo)48(12)1506-1508(1995) 2.Lam, Y.K.T., Hensens, O., Helms, G., et al.L-755,805, a new polyketide endothelin binding inhibitor from an actinomyceteTetrahedron Lett.36(12)2013-2016(1995)