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- DNA Methyltransferase
- Bobcat 339
Bobcat 339
A cytosine derivative
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包装价格促销价数量
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1mg￥450.00360.00- +
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5mg￥1362.001090.00- +
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10mg￥2512.002010.00- +
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25mg￥5675.004540.00- +
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- 货号: ajcx21820
- CAS: 2280037-51-4
- 别名: BC339
- 分子式: C16H12ClN3O
- 分子量: 297.7
- 纯度: ＞98%
- 溶解度: DMF: 1 mg/ml,DMSO: 1 mg/ml,DMSO:PBS (pH 7.2) (1:8): 0.11 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
Bobcat 339 is an inhibitor of ten-eleven translocation methylcytosine dioxygenase 1 (TET1) and TET2 (IC50s = 33 and 73 µM, respectively).1 It is selective for TET1 and TET2 over DNA methyltransferase 3a (DNMT3a) at 500 µM. Bobcat 339 (10 µM) reduces DNA 5-hydroxymethylcytosine (5-hmC) levels in HT22 hippocampal neurons.
1.Chua, G.N.L., Wassarman, K.L., Sun, H., et al.Cytosine-based TET enzyme inhibitorsACS Med. Chem. Lett.10(2)180-185(2019)
