Bosentan-d4

An internal standard for the quantification of bosentan

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
5mg

￥4612.00

3690.00

- +
25mg

￥16150.00

12920.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajcx21838
CAS: 1065472-77-6
别名: 波生坦-D4
分子式: C27H25D4N5O6S
分子量: 555.6
纯度: >98%
溶解度: Chloroform: soluble,Ethanol: soluble,Methanol: Soluble
储存: Store at -20°C
库存: 现货

Background

Bosentan-d₄ is an internal standard for the quantification of bosentan by GC- or LC-MS. Bosentan is an antagonist of the endothelin receptors type A (K_i = 6.5 nM) and type B (K_i = 340 nM).^1,2

1.Jae, H.S., Winn, M., Dixon, D.B., et al.Pyrrolidine-3-carboxylic acids as endothelin antagonists. 2. Sulfonamide-based ETA/ETB mixed antagonistsJ. Med. Chem.40(20)3217-3227(1997) 2.Wu, C., Decker, E.R., Blok, H., et al.Discovery, modeling, and human pharmacokinetics of N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)-thiophene-2-carboxamide (TBC3711), a second generation, ETA selective, and orally bioavailable endothelin antagonistJ. Med. Chem.47(8)1969-1986(2004)