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  • Bromoenol lactone-d7
Bromoenol lactone-d7的可视化放大

Bromoenol lactone-d7

A neuropeptide with diverse biological activities

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Bromoenol lactone-d7的二维码
  • 库存: 现货
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  • 100ug
    ¥600.00
    480.00
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  • 500ug
    ¥2712.00
    2170.00
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  • 1mg
    ¥4762.00
    3810.00
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  • 货号: ajcx21856
  • CAS: N/A
  • 别名: (6E)-Bromoenol lactone-d7
  • 分子式: C16H6D7BrO2
  • 分子量: 324.2
  • 纯度: >98%
  • 溶解度: DMF: 50 mg/ml,DMSO: 25 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): < 50 μg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

Bromoenol lactone-d7 (BEL-d7) contains seven deuterium atoms at the 2, 3, 4, 5, 6, 7, and 8 positions. It is intended for use as an internal standard for the quantification of BEL by GC- or LC-mass spectrometry (MS). BEL is a selective, potent, irreversible, mechanism-based inhibitor of phospholipase A2 (iPLA2) with a Ki value of 180 nM.1 It also inhibits macrophage iPLA2 in a concentration-dependent manner with an IC50 value of 60 nM and is an effective enzyme-activated irreversible inhibitor of chymotrypsin (Ki = 636 nM).2,3



1.Hazen, S.L., Zupan, L.A., Weiss, R.H., et al.Suicide inhibition of canine myocardial cytosolic calcium-independent phospholipase A2The Journal of Biological Chemisty2667227-7232(1991) 2.Ackermann, E.J., Conde-Frieboes, K., and Dennis, E.A.Inhibition of macrophage Ca2+-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketonesThe Journal of Biological Chemisty270445-450(1995) 3.Balsinde, J., Bianco, I.D., Ackermann, E.J., et al.Inhibition of calcium-independent phospholipase A2 prevents arachidonic acid incorporation and phospholipid remodeling in P388D1 macrophagesProceedings of the National Academy of Sciences of the United States of America928527-8531(1995)

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