C16 Ceramide-d7 (d18:1-d7/16:0)
An internal standard for the quantification of C16 ceramide
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包装价格促销价数量
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500ug￥6137.004910.00- +
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1mg￥11050.008840.00- +
- 货号: ajcx21880
- CAS: 1840942-13-3
- 别名: Palmitoyl Ceramide-d7
- 分子式: C34H60D7NO3
- 分子量: 545
- 纯度: ＞98%
- 溶解度: DMF: 0.15 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
C16 Ceramide-d7 is intended for use as an internal standard for the quantification of C16 ceramide by GC- or LC-MS. C16 Ceramide is an endogenous ceramide, generated by ceramide synthase 6 (CerS6), that acts as a lipid second messenger to regulate apoptosis and stress signaling.[1] Accumulation of C16 ceramide through PPMP (30 μM) or MAPP (50 μM) treatment or from addition of 100 μM synthetic C16 ceramide induces apoptosis in neutrophil cultures via caspase-3 activation.[2]
Reference:
[1].White-Gilbertson, S., Mullen, T., Senkal, C., et al.Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase 3 in colon cancer cellsOncogene28(8)1132-1141(2009)
[2].Seumois, G., Fillet, M., Gillet, L., et al.De novo C16- and C24-ceramide generation contributes to spontaneous neutrophil apoptosisJ. Leukoc. Biol.81(6)1477-1486(2007)
