A neuropeptide with diverse biological activities
C18 Ganglioside GM3-d3 is intended for use as an internal standard for the quantification of ganglioside GM3 by GC- or LC-MS. Ganglioside GM3 is a simple monosialoganglioside that demonstrates both antiproliferative and proapoptotic effects in tumor cells by modulating cell adhesion, proliferation, and differentiation.1,2 When used at a concentration of 20 μM, it suppresses angiogenesis and reduces endothelial cell proliferation and migration by inhibiting VEGFR2 and Akt phosphorylation.1 Furthermore, ganglioside GM3 has been shown to induce the dissociation of the insulin receptor-caveolin-1 complex from lipid microdomains, functioning as an inhibitor of insulin signaling and contributing to insulin resistance.3 [Matreya, LLC. Catalog No. 2052]
1.Mukherjee, P., Faber, A.C., Shelton, L.M., et al.Thematic review series: Sphingolipids. Ganglioside GM3 suppresses the proangiogenic effects of vascular endothelial growth factor and ganglioside GD1aJ. Lipid Res.49(5)929-938(2008) 2.Seyfried, T.N., and Mukherjee, P.Ganglioside GM3 is antiangiogenic in malignant brain cancerJ. Oncol.961243(2010) 3.Kabayama, K., Sato, T., Saito, K., et al.Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistanceProc. Natl. Acad. Sci. USA104(34)13678-13683(2007)
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