CAY10753
A TNKS2 inhibitor
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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1mg￥1012.00810.00- +
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5mg￥4012.003210.00- +
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10mg￥7037.005630.00- +
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- 货号: ajcx22026
- CAS: N/A
- 别名:
- 分子式: C24H26N6O2S2
- 分子量: 494.6
- 纯度: ＞98%
- 溶解度: DMSO: slightly soluble,Methanol: slightly soluble
- 储存: Store at -20°C
- 库存: 现货
Background
CAY10753 is an inhibitor of tankyrase 2 (TNKS2; IC50 = 0.3 nM).1 It is selective for TNKS2 over TNKS1 (IC50 = 6.1 nM), as well as poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 (IC50s = 89.6 and 37.8 nM, respectively). CAY10753 inhibits proliferation of DLD-1 colorectal cancer cells when used at a concentration of 1 µM.
1.Tomassi, S., Pfahler, J., Mautone, N., et al.From PARP1 to TNKS2 inhibition: A structure-based approachMed. Chem. Lett.(2020)
