CAY10760
An inhibitor of the RAD51-BRCA2 interaction
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包装价格促销价数量
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5mg￥2300.001840.00- +
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10mg￥4112.003290.00- +
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25mg￥9325.007460.00- +
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50mg￥15950.0012760.00- +
- 货号: ajcx22032
- CAS: 391889-85-3
- 别名:
- 分子式: C28H24ClN3O3
- 分子量: 486
- 纯度: ＞98%
- 溶解度: DMF: 11mg/mL,DMF:PBS (pH 7.2) (1:2): 0.3mg/mL,DMSO: 10mg/mL
- 储存: Store at -20°C
- 库存: 现货
Background
CAY10760 is an inhibitor of the protein-protein interaction between RAD51 recombinase and BRCA2 (EC50 = 19 µM in a cell-free competitive ELISA).1 It decreases homologous recombination by 54% in wild-type BRCA2-expressing BxPC-3 pancreatic cancer cells when used at a concentration of 20 µM. CAY10760 (20 µM) decreases proliferation of BxPC-3, as well as mutant BRCA2-expressing Capan-1, cancer cells when used alone or in combination with the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib .
1.Bagnolini, G., Milano, D., Manerba, M., et al.Synthetic lethality in pancreatic cancer: Discovery of a new RAD51-BRCA2 small molecule disruptor that inhibits homologous recombination and synergizes with olaparibJ. Med. Chem.63(5)2588-2619(2020)
