An internal standard for the quantification of cefuroxime
Cefuroxime-d3 is intended for use as an internal standard for the quantification of cefuroxime by GC- or LC-MS. Cefuroxime is a cephalosporin antibiotic with broad-spectrum activity against Gram-positive and Gram-negative bacteria including S. pyogenes, S. pneumoniae, S. viridans, E. coli, P. mirabilis, H. influenzae, and N. gonorrhoeae (mean MICs = 0.005-8.2 μg/ml).1 Like other cephalosporins, cefuroxime inhibits peptidoglycan crosslinking and bacterial cell wall synthesis.2 It is resistant to hydrolysis by bacterial β-lactamases, increasing its efficacy against β-lactamase-producing Gram-negative bacteria.3 Cefuroxime is protective against Gram-positive and Gram-negative infections in vivo with mean ED50 values ranging from 2 to 35 and 1 to 55 mg/kg, in mice and rats, respectively.4 Formulations containing cefuroxime have been used to treat urinary tract infections.
1.O'Callaghan, C.H., Sykes, R.B., Griffiths, A., et al.Cefuroxime, a new cephalosporin antibiotic: Activity in vitroAntimicrob. Agents Chemother.9(3)511-519(1976) 2.Curtis, N.A.C., Hughes, J.M., and Ross, G.W.Inhibition of peptidoglycan cross-linking in growing cells of Escherichia coli by penicillins and cephalosporins, and its prevention by R factor-mediated beta-lactamaseAntimicrob. Agents Chemother.9(2)208-213(1976) 3.Richmond, M.H., and Wotton, S.Comparative study of seven cephalosporins: Susceptibility to beta-lactamases and ability to penetrate the surface layers of Escherichia coliAntimicrob. Agents Chemother.10(2)219-222(1976) 4.Ryan, D.M., O'Callaghan, C.H., and Muggleton, P.W.Cefuroxime, a new cephalosporin antibiotic: Activity in vivoAntimicrob. Agents Chemother.9(3)520-525(1976)
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