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  • CEP-Lysine-d4
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CEP-Lysine-d4

A neuropeptide with diverse biological activities

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CEP-Lysine-d4的二维码
  • 库存: 现货
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  • 包装
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    促销价
    数量
  • 500ug
    ¥3600.00
    2880.00
    - +
  • 1mg
    ¥6862.00
    5490.00
    - +
  • 5mg
    ¥28637.00
    22910.00
    - +
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  • 货号: ajcx22056
  • CAS: N/A
  • 别名:
  • 分子式: C13H16D4N2O4
  • 分子量: 272.3
  • 纯度: >98%
  • 溶解度: DMF: 20 mg/ml,DMSO: 20 mg/ml,PBS (pH 7.2): 10 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

CEP-Lysine-d4 contains four deuterium atoms at the carboxyethyl 2,3',3,3' positions. It is intended for use as an internal standard for the quantification of CEP-lysine by GC- or LC-mass spectrometry (MS). Docosahexaenoic acid (DHA) is an ω-3 polyunsaturated fatty acid that is abundant in the brain and in photoreceptor cell membranes in the retina. Oxidative cleavage of phospholipids containing DHA produces reactive electophilic phospholipid fragments, including 4-hydroxy-7-oxohept-5-enoates.1 These can interact with the primary amine group of lysyl residues to produce 2-(ω-carboxyethyl)pyrrole (CEP) derivatives, which are abundant in certain diseases.2,3 Advanced glycation end products, including CEP-lysine are biomarkers for age-related macular degeneration.4,5 CEP-lysine-d4 is a deuterated form of CEP-lysine.



1.Lu, L., Gu, X., Hong, L., et al.Synthesis and structural characterization of carboxyethylpyrrole-modified proteins: Mediators of age-related macular degenerationBioorganic & Medicinal Chemistry177548-7561(2009) 2.Gu, X., Sun, M., Gugiu, B., et al.Oxidatively truncated docosahexaenoate phospholipids: Total synthesis, generation, and peptide adduction chemistryThe Journal of Organic Chemistry683749-3761(2003) 3.Crabb, J.W., Miyagi, M., Gu, X., et al.Drusen proteome analysis: An approach to the etiology of age-related macular degenerationProceedings of the National Academy of Sciences of the United States of America99(23)14682-14687(2002) 4.Gu, J., Pauer, G.J.T., Yue, X., et al.Assessing susceptibility to age-related macular degeneration with proteomic and genomic biomarkersMol.Cell.Proteomics81338-1349(2009) 5.Ni, J., Yuan, X., Gu, J., et al.Plasma protein pentosidine and carboxymethyllysine, biomarkers for age-related macular degenerationMol.Cell.Proteomics81921-1933(2009)

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