A fungal metabolite
Chaetoviridin A is a fungal metabolite that has been found in Chaetomium.1 Plant pathogenic, antitumor, and cholesteryl ester transfer protein (CETP) inhibitory activity attributed to chaetoviridin A was determined prior to its structural reassignment by total synthesis, NMR, and circular dichroism analysis.1,2,3,4
1.Makrerougras, M., Coffinier, R., Oger, S., et al.Total synthesis and structural revision of chaetoviridins AOrg. Lett.19(15)4146-4149(2017) 2.Park, J.-H., Choi, G.J., Jang, K.S., et al.Antifungal activity against plant pathogenic fungi of chaetoviridins isolated from Chaetomium globosumFEMS Microbiol. Lett.252(2)309-313(2005) 3.Yasukawa, K., Takahashi, M., Natori, S., et al.Azaphilones inhibit tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in miceOncology51(1)108-112(1994) 4.Tomoda, H., Matsushima, C., Tabata, N., et al.Structure-specific inhibition of cholesteryl ester transfer protein by azaphilonesJ. Antibiot. (Tokyo)52(2)160-170(1999)
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