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- Ribosomal S6 Kinase (RSK)
- Deacetylforskolin
Deacetylforskolin
A diterpene with diverse biological activities
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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1mg￥825.00660.00- +
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5mg￥3312.002650.00- +
- 货号: ajcx22208
- CAS: 64657-20-1
- 别名: 脱乙酰毛喉素来源于毛喉鞘蕊花
- 分子式: C20H32O6
- 分子量: 368.5
- 纯度: ＞98%
- 溶解度: Chloroform: slightly soluble,Methanol: slightly soluble
- 储存: Store at -20°C
- 库存: 现货
Background
Deacetylforskolin is a diterpene and a derivative of forskolin that has been found in C. forskohlii and has diverse biological activities.1,2,3,4 It activates rat adipocyte adenylyl cyclase (IC50 = 20 µM) and inhibits glucose transport in rat adipocyte plasma membranes.2 Deactylforskolin (30-1,000 µg/kg) reduces blood pressure in spontaneously hypertensive rats.3 It also attenuates hypercapnia-induced impairments in the passive avoidance response in mice.4
1.Gabetta, B., Zini, G., and Danieli, B.Minor Diterpenoids of Coleus forskohliiPhytochemistry28(3)859-862(1989) 2.Joost, H.G., Habberfield, A.D., Simpson, I.A., et al.Activation of adenylate cyclase and inhibition of glucose transport in rat adipocytes by forskolin analogues: structural determinants for distinct sites of actionMol. Pharmacol.33(4)449-453(1988) 3.Bhat, S.V., Dohadwalla, A.N., Bajwa, B.S., et al.The antihypertensive and positive inotropic diterpene forskolin: Effects of structural modifications on its activityJ. Med. Chem.26(4)486-492(1983) 4.McCulloch, A.J., Thomson, T.A., and Deacon, R.Hypoxic amnesia and its reversal with forskolinBiochem. Soc. Trans.17(1)212-213(1988)
