A neuropeptide with diverse biological activities
Decitabine-15N4 is intended for use as an internal standard for the quantification of decitabine . Decitabine is a 2'-deoxy analog of 5-azacytidine that induces dose-dependent inhibition of DNA methyltransferases and hypomethylation of DNA.1,2,3 This action is useful in conditions characterized by DNA hypermethylation, as is found in myelodysplastic syndromes.4
1.Esteller, M.Epigenetics in cancerN. Engl. J. Med.3581148-1159(2008) 2.Lyko, F., and Brown, R.DNA methyltransferase inhibitors and the development of epigenetic cancer therapiesJ. Natl. Cancer Inst.97(20)1498-1506(2005) 3.Stresemann, C., Brueckner, B., Musch, T., et al.Functional diversity of DNA methyltransferase inhibitors in human cancer cell linesCancer Res.66(5)2794-2800(2006) 4.Ornstein, M.C., and Sekeres, M.A.Combination strategies in myelodysplastic syndromesInt. J. Hematol.9526-33(2012)
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