Desloratadine-d4
An internal standard for the quantification of desloratadine
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包装价格促销价数量
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500ug￥1187.00950.00- +
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1mg￥2012.001610.00- +
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5mg￥8187.006550.00- +
- 货号: ajcx22244
- CAS: 2713301-38-1
- 别名: Sch34117-d4
- 分子式: C19H15ClD4N2
- 分子量: 314.9
- 纯度: ＞98%
- 溶解度: DMF: 30 mg/ml,DMSO: 10 mg/ml,Ethanol: 30 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
Desloratadine-d4 is intended for use as an internal standard for the quantification of desloratadine by GC- or LC-MS. Desloratadine is an orally bioavailable metabolite of the non-sedating antihistamine loratadine .1,2 It is a tricyclic antagonist of the histamine H1 receptor (Ki = 0.97 nM). Formulations containing desloratadine have been used in the treatment of seasonal allergic rhinitis and chronic idiopathic urticaria.
1.Lewis, T.A., Young, M.A., Arrington, M.P., et al.Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activityBioorganic & Medicinal Chemistry Letters14(22)5591-5594(2004) 2.Church, M.K., and Church, D.S.Pharmacology of antihistaminesIndian J. Dermatol.58(3)219-224(2013)
