A neuropeptide with diverse biological activities
Desoximetasone-d3 is intended for use as an internal standard for the quantification of desoximetasone by GC- or LC-MS. Desoximetasone is a glucocorticoid.1 In vivo, desoximetasone (0.001-0.1 mg) reverses increases in epidermal cell proliferation induced by phorbol 12-myristate 13-acetate in SENCAR mice when administered topically. It also reduces TPA-induced expression of IL-6, COX-2, iNOS, and c-Jun mRNA levels in the skin of SENCAR mice, indicating anti-inflammatory action. Formulations containing desoximetasone have been used in the treatment of psoriasis and atopic dermatitis.
1.Kowalczyk, P., Junco, J.J., Kowalczyk, M.C., et al.The effects of dissociated glucocorticoids RU24858 and RU24782 on TPA-induced skin tumor promotion biomarkers in SENCAR miceMol. Carcinog.53(6)488-497(2014)
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