D-Glucosamine-6-phosphate (hydrate)

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库存: 现货

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50mg

￥1012.00

810.00

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100mg

￥1812.00

1450.00

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250mg

￥4262.00

3410.00

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Background

D-Glucosamine-6-phosphate (D-GlcN-6-P) is a monosaccharide intermediate of the hexosamine biosynthetic pathway.¹ It is formed from D-fructose-6-phosphate by glucosamine-6-phosphate synthase (GlmS) in the presence of glutamine or from D-glucosamine by N-acetyl-D-glucosamine (GlcNAc) kinase.^2,3,4 D-GlcN-6-P binds the GlmS riboswitch (K_i = 380 µM), a ribozyme located in the 5'-UTR of the gene encoding GlmS that, when bound by D-GlcN-6-P, inhibits GlmS production and decreases D-GlcN-6-P levels.^2,5 It is a precursor in the biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc), a substrate for protein glycosylation and a component of bacterial cell walls.^4,6

1.Buse, M.G.Hexosamines, insulin resistance, and the complications of diabetes: Current statusAm. J. Physiol. Endocrinol. Metab.290(1)E1-E8(2006) 2.Bearne, S.L., and Blouin, C.Inhibition of Escherichia coli glucosamine-6-phosphate synthase by reactive intermediate analogues. The role of the 2-amino function in catalysisJ. Biol. Chem.275(1)135-140(2000) 3.Akella, N.M., Ciraku, L., and Reginato, M.J.Fueling the fire: Emerging role of the hexosamine biosynthetic pathway in cancerBMC Biol.17(1)52(2019) 4.Chiaradonna, F., Ricciardiello, F., and Palorini, R.The nutrient-sensing hexosamine biosynthetic pathway as the hub of cancer metabolic rewiringCells7(6)53(2018) 5.Cochrane, J.C., Lipchock, S.V., and Strobel, S.A.Structural investigation of the GlmS ribozyme bound to its catalytic cofactorChem. Biol.14(1)97-105(2007) 6.Rodríguez-Díaz, J., Rubio-Del-Campo, A., and Yebra, M.J.Regulatory insights into the production of UDP-N-acetylglucosamine by Lactobacillus caseiBioengineered3(6)339-342(2012)