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  • D-threo-PPMP (hydrochloride)
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D-threo-PPMP (hydrochloride)

A GlyCer synthetase inhibitor

原价
¥5912-5912
价格
4730-4730
D-threo-PPMP (hydrochloride)的二维码

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  • 货号: ajcx22384
  • CAS: 139889-65-9
  • 别名: D-threo-1-phenyl-2-Palmitoylamino-3-morpholino-1-propanol
  • 分子式: C29H50N2O3.HCl
  • 分子量: 511.2
  • 纯度: >98%
  • 溶解度: Ethanol: Soluble,Methanol: Soluble
  • 储存: Store at -20°C
  • 库存: 现货

Background

D-threo-PPMP is a glucosylceramide (GlyCer) synthetase inhibitor.1,2 It is the active enanantiomer and enzymatic inhibitory component of the racemic DL-threo-PPMP . In MDCK kidney epithelial cells, D-threo-PPMP induces a 70% reduction in cell growth in vitro at 20 µM and significantly inhibits DNA synthesis at 3 µM.3 [Matreya, LLC. Catalog No. 1865]



1.Shen, W., Henry, A.G., Paumier, K.L., et al.Inhibition of glucosylceramide synthase stimulates autophagy flux in neuronsJ. Neurochem.129(5)884-894(2014) 2.Lee, L., Abe, A., and Shayman, J.A.Improved inhibitors of glucosylceramide synthaseJ. Biol. Chem.274(21)14662-14669(1999) 3.Abe, A., Inokuchi, J.-i., Jimbo, M., et al.Improved inhibitors of glucosylceramide synthaseJ. Biochem.111(2)191-196(1992)

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