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  • Edoxaban-d6
Edoxaban-d6的可视化放大

Edoxaban-d6

An internal standard for the quantification of edoxaban

原价
¥6662-11887
价格
5330-9510
Edoxaban-d6的二维码

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  • 货号: ajcx22392
  • CAS: 1304701-57-2
  • 别名: 依杜沙班杂质,DU-176-d6
  • 分子式: C24H24ClD6N7O4S
  • 分子量: 554.1
  • 纯度: >98%
  • 溶解度: DMSO: Soluble,Methanol: Soluble
  • 储存: Store at -20°C
  • 库存: 现货

Background

Edoxaban-d6 is intended for use as an internal standard for the quantification of edoxaban by GC- or LC-MS. Edoxaban is an orally bioavailable and potent inhibitor of factor Xa (Kis = 0.561 and 0.903 nM for free and complexed human factor Xa, respectively).1 It is >10,000-fold selective for factor Xa over thrombin, FVIIa/sTF, FXIa, tPA, aPC, trypsin, plasmin, and chymotrypsin. Edoxaban prolongs prothrombin, activated partial thromboplastin, and thrombin clotting times in a concentration-dependent manner ex vivo in human plasma. Oral administration of edoxaban (0.5-12.5 mg/kg) reduces thrombus formation and prolongs prothrombin time in a dose-dependent manner in rat and rabbit models of venous stasis thrombosis. It also reduces thrombus formation in a rat model of platinum wire-induced venous thrombosis. Formulations containing edoxaban have been used to prevent stroke in patients with atrial fibrillation.



1.Furugohri, T., Isobe, K., Honda, Y., et al.DU-176b, a potent and orally active factor Xa inhibitor: In vitro and in vivo pharmacological profilesJ. Thromb. Haemost.6(9)1542-1549(2008)

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