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  • Eicosapentaenoic Acid ethyl ester-d5
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Eicosapentaenoic Acid ethyl ester-d5

A neuropeptide with diverse biological activities

原价
¥937-6462
价格
750-5170
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  • 货号: ajcx22394
  • CAS: N/A
  • 别名: EPA ethyl ester-d5
  • 分子式: C22H29D5O2
  • 分子量: 335.5
  • 纯度: >98%
  • 溶解度: DMF: >100 mg/ml,DMSO: >100 mg/ml,Ethanol: >100 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

Fish oils in the diet have anti-inflammatory and cardiovascular benefits due to an abundance of ω-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid (EPA).1 EPA ethyl ester is a stabilized ethyl ester form of this ω-3 C20:5 PUFA. EPA competitively inhibits the metabolism of (ω-6) arachidonic acid by cyclooxygenase enzymes, suggesting that EPA ethyl ester may also directly modulate the actions of enzymes involved in fatty acid metabolism.2 In addition, dietary EPA ethyl ester in rats increases fatty acid β-oxidation enzyme levels, indicating that EPA ethyl ester may alter the expression of genes related to fatty acid metabolism.3,4 Consistent with this concept, dietary supplementation with EPA ethyl ester in rats also down-regulates lipogenic genes, and decreases plasma cholesterol and triglyceride levels.5 Also, in rats fed a high-fat diet, supplementation with EPA ethyl ester blocks induced insulin resistance and corrects changes in adiponectin levels and TNF-α expression.6



1.von Schacky, C.A review of omega-3 ethyl esters for cardiovascular prevention and treatment of increased blood triglyceride levelsVascular Health and Risk Management2(3)251-262(2006) 2.Wada, M., DeLong, C.J., Hong, Y.H., et al.Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and productsJ. Biol. Chem.282(31)22254-22266(2007) 3.Hong, D.D., Takahashi, Y., Kushiro, M., et al.Divergent effects of eicosapentaenoic and docosahexaenoic acid ethyl esters, and fish oil on hepatic fatty acid oxidation in the ratBiochimica et Biophysica Acta163529-36(2003) 4.Arachchige, P.G., Takahashi, Y., and Ide, T.Dietary sesamin and docosahexaenoic and eicosapentaenoic acids synergistically increase the gene expression of enzymes involved in hepatic peroxisomal fatty acid oxidation in ratsMetabolism: Clinical and Experimental55381-390(2006) 5.Pérez-Echarri, N., Pérez-Matute, P., Marcos-Gómez, B., et al.Down-regulation in muscle and liver lipogenic genes: EPA ethyl ester treatment in lean and overweight (high-fat-fed) ratsJournal of Nutritional Biochemistry(2008) 6.Pérez-Matute, P., Pérez-Echarri, N., Martínez, J.A., et al.Eicosapentaenoic acid actions on adiposity and insulin resistance in control and high-fat-fed rats: Role of apoptosis, adiponectin and tumor necrosis factor-αBritish Journal of Nutrition97389-398(2007)

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