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- Interleukin-1 receptor-associated kinase (IRAK)
- Esculin (hydrate)
Esculin (hydrate)
A coumarin with antioxidant and anti-inflammatory activities
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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5g￥600.00480.00- +
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10g￥1087.00870.00- +
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25g￥2400.001920.00- +
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50g￥4162.003330.00- +
- 货号: ajcx22440
- CAS: N/A
- 别名: Aesculin, Enallachrome
- 分子式: C15H16O9.XH2O
- 分子量: 340.3
- 纯度: ＞98%
- 溶解度: DMF: 25 mg/ml,DMSO: 16 mg/ml,Ethanol: 3 mg/ml,PBS (pH 7.2): 5 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
Esculin is a coumarin that has been found in A. hippocastanum and has antioxidant and anti-inflammatory activities.1,2 It reduces the size of gastric ulcers and decreases increases in the levels of malondialdehyde (MDA) and the activity of myeloperoxidase (MPO) and catalase in a mouse model of ethanol-induced ulcers when used at a dose of 25 mg/kg.1 Esculin (20 mg/kg) decreases LPS-induced increases in the levels of TLR4, MyD88, IRAK4, and phosphorylated NF-?B in the lung, as well as levels of IL-1β, IL-6, and TNF-α in the bronchoalveolar lavage fluid (BALF) in a mouse model of acute lung injury.2
1.Rios, E.R., Rocha, N.F., Ven?ncio, E.T., et al.Mechanisms involved in the gastroprotective activity of esculin on acute gastric lesions in miceChem. Biol. Interact.188(1)246-254(2010) 2.Tianzhu, Z., and Shumin, W.Esculin inhibits the inflammation of LPS-induced acute lung injury in mice via regulation of TLR/NF-κB pathwaysInflammation38(4)1529-1536(2015)
