Fenbendazole-d3

An internal standard for the quantification of fenbendazole

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库存: 现货

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数量
1mg

￥862.00

690.00

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5mg

￥1712.00

1370.00

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10mg

￥2825.00

2260.00

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货号: ajcx22478
CAS: 1228182-47-5
别名: 芬苯达唑 d3
分子式: C15H10D3N3O2S
分子量: 302.4
纯度: >98%
溶解度: DMSO: slightly soluble,Methanol: slightly soluble
储存: Store at -20°C
库存: 现货

Background

Fenbendazole-d₃ is intended for use as an internal standard for the quantification of fenbendazole by GC- or LC-MS. Fenbendazole is a benzimidazole anthelmintic.¹ It is active against Giardia in vitro (IC₅₀ = 0.3 μM). Fenbendazole (20 mg/kg) prevents infiltration of parasites into the brain in a rabbit model of E. cuniculi infection.² It also activates HIF-1α and prevents oxidative stress-induced death in primary neurons in vitro.³

1.Morgan, U.M., Reynoldson, J.A., and Thompson, R.C.A.Activities of several benzimidazoles and tubulin inhibitors against Giardia spp. in vitroAntimicrob. Agents Chemother.37(2)328-331(1993) 2.Suter, C., Müller-Doblies, U.U., Hatt, J.-M., et al.Prevention and treatment of Encephalitozoon cuniculi infection in rabbits with fenbendazoleVet. Rec. 148(15)478-480(2001) 3.Aleyasin, H., Karuppagounder, S.S., Kumar, A., et al.Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulinAntioxid. Redox Signal.22(2)121-134(2015)