A fungicide that inhibits the sterol pathway
Fenpropimorph is a fungicide that inhibits the sterol pathway.1 It inhibits δ8-δ7-sterol isomerase in yeast at low concentrations, with δ14-sterol reductase being blocked at higher levels, preventing the biosynthesis of ergosterol .2 Fenpropimorph is also able to inhibit sterol synthesis in certain plants and mammalian cells.1,3
1.Costet, M.F., Achouri, M.E., Charlet, M., et al.Ecdysteroid biosynthesis and embryonic development are disturbed in insects (Locusta migratoria) reared on plant diet (Triticum sativum) with a selectively modified sterol profileProc. Natl. Acad. Sci. USA84(3)643-647(1987) 2.Marcireau, C., Guilloton, M., and Karst, F.In vivo effects of fenpropimorph on the yeast Saccharomyces cerevisiae and determination of the molecular basis of the antifungal propertyAntimicrob. Agents Chemother.34(6)989-993(1990) 3.Corio-Costet, M.F., Gerst, N., Benveniste, P., et al.Inhibition by the fungicide fenpropimorph of cholesterol biosynthesis in 3T3 fibroblastsBiochem J.256(3)829-834(1988)
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