- 首页
- 5-HT Receptor
- Flibanserin-d4 (hydrochloride)
Flibanserin-d4 (hydrochloride)
A neuropeptide with diverse biological activities
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
-
包装价格促销价数量
-
1mg￥2587.002070.00- +
-
5mg￥12075.009660.00- +
- 货号: ajcx22498
- CAS: N/A
- 别名: BIMT-17-d4 hydrochloride; BIMT-17BS-d4 hydrochloride
- 分子式: C20H17D4F3N4O.HCl
- 分子量: 430.9
- 纯度: ＞98%
- 溶解度: DMSO: slightly soluble,Methanol: slightly soluble
- 储存: Store at -20°C
- 库存: 现货
Background
Flibanserin-d4 is intended for use as an internal standard for the quantification of flibanserin by GC- or LC-MS. Flibanserin is a full agonist of the serotonin 5-HT1A receptor and an antagonist of 5-HT2A (Kis = 1 and 49 nM, respectively).1 It also binds to dopamine D4 receptors with Ki values ranging from 4-24 nM, but demonstrates no affinity for the other 5-HT subtypes or other neurotransmitter receptors.1 In vitro, flibanserin has been shown to reduce forskolin-stimulated cAMP formation in cells and rat tissues and to antagonize the accumulation of phosphatidyl inositol turnover induced by 5-HT in the mouse cortex.1 At 10 mg/kg, flibanserin can reduce serotonin in the prefrontal cortex and dorsal raphe of conscious rats while increasing extracellular noradrenaline and dopamine.1
1.Invernizzi, R.W., Sacchetti, G., Parini, S., et al.Flibanserin, a potential antidepressant drug, lowers 5-HT and raises dopamine and noradrenaline in the rat prefrontal cortex dialysate: Role of 5-HT1A receptorsBr. J. Pharmacol.139(7)1281-1288(2003)
