Fosinopril-d7 (sodium salt)

An internal standard for the quantification of fosinopril

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1mg

￥7500.00

6000.00

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货号: ajcx22524
CAS: 1217819-83-4
别名:
分子式: C30H38D7NO7P.Na
分子量: 592.7
纯度: >98%
溶解度: Acetonitrile:Methanol (1:1): Soluble,DMSO: Soluble,Water: Soluble
储存: Store at -20°C
库存: 现货

Background

Fosinopril-d₇ is intended for use as an internal standard for the quantification of fosinopril by GC- or LC-MS. Fosinopril is a prodrug form of the angiotensin-converting enzyme (ACE) inhibitor fosinoprilat.¹ Oral administration of fosinopril inhibits angiotensin I-induced pressor responses in normotensive rats, dogs, and monkeys when administered at doses of 15, 15, and 10 µmol/kg, respectively. Fosinopril (2.5 mg/kg) reduces fractional shortening and decreases left ventricular size in a porcine model of congestive heart failure.² Formulations containing fosinopril have been used in the treatment of hypertension and congestive heart failure.

1.DeForrest, J.M., Waldron, T.L., Harvey, C., et al.Fosinopril, a phosphinic acid inhibitor of angiotensin I converting enzyme: In vitro and preclinical in vivo pharmacologyJ. Cardiovasc. Pharmacol.14(5)730-736(1989) 2.McElmurray, J.H., III, Mukherjee, R., New, R.B., et al.Angiotensin-converting enzyme and matrix metalloproteinase inhibition with developing heart failure: Comparative effects on left ventricular function and geometryJ. Pharmacol. Exp. Ther.291(2)799-811(1999)