A neuropeptide with diverse biological activities
Foxy-5 is a Wnt5a peptide mimetic with anticancer activity.1,2 It increases adhesion and reduces cell motility of MDA-MB-468 breast cancer cells when used at concentrations ranging from 1 to 1,000 µM.1 Foxy-5 (2 mg/kg) reduces the number of lymph node metastases without affecting primary tumor growth in a DU145-Luc mouse xenograft model.2
1.S?fholm, A., Leandersson, K., Dejmek, J., et al.A formylated hexapeptide ligand mimics the ability of Wnt-5a to impair migration of human breast epithelial cellsJ. Biol. Chem.281(5)2740-2749(2006) 2.Canesin, G., Evans-Axelsson, S., Hellsten, R., et al.Treatment with the WNT5A-mimicking peptide Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse modelPLoS One12(9)e0184418(2017)
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