现货大促销,价格低至8折起,量大更优惠,详细咨询客服
全部分类
全部分类
  • Genistein-d4
Genistein-d4的可视化放大

Genistein-d4

An internal standard for the quantification of genistein

原价
¥875-7112
价格
700-5690
Genistein-d4的二维码

所有产品仅用于科学研究,我们不为任何个人用途提供产品和服务

询价有惊喜,量大更优惠 点击这里给我发消息

  • 库存: 现货
可选包装 >>>
首页
  • 货号: ajcx22562
  • CAS: 187960-08-3
  • 别名: 金雀异黄酮-D4,NPI 031L-d4
  • 分子式: C15H6D4O5
  • 分子量: 274.3
  • 纯度: >98%
  • 溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:6): 1 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

Genistein-d4 is intended for use as an internal standard for the quantification of genistein by GC- or LC-MS. Genistein is an isoflavonoid phytoestrogen that has been found in soybeans (G. max/S. hispida) and has kinase inhibitory, anticancer, pro-cancer, hepatoprotective, and antiviral properties.1 It inhibits the tyrosine kinases EGFR, pp50v-Src, and pp110gag-fes (IC50 = 6, 7-8, and 6.5 µg/ml, respectively) and decreases EGF-induced serine, threonine, and tyrosine phosphorylation of EGFR in A431 cells when used at a concentration of 20 µg/ml.2 Genistein inhibits proliferation and induces apoptosis in a variety of cancer cells, including Bel 7402 hepatocellular carcinoma cells when used at a concentration of 10 µg/ml.1,3 It reduces tumor invasion and angiogenesis in a Bel 7402 mouse subrenal capsule xenograft model when administered at a dose of 50 mg/kg per day.3 However, when administered at the same dose on postnatal days 1-5, genistein increases the incidence of uterine adenocarcinoma in a mouse model of cancer induced by the estrogen receptor agonist diethylstilbestrol .4 It reduces lipid accumulation and inflammation in the liver of ovariectomized (OVX) and non-OVX female rats in a model of high-fat high-fructose diet-induced nonalcoholic hepatosteatosis (NASH) when administered at a dose of 16 mg/kg per day.5 Genistein (10 µM) also inhibits HIV-1 DNA synthesis in resting CD4+ T cells.6



1.Spagnuolo, C., Russo, G.L., Orhan, I.E., et al.Genistein and cancer: Current status, challenges, and future directionsAdv. Nutr.6(4)408-419(2015) 2.Akiyama, T., Ishida, J., Nakagawa, S., et al.Genistein, a specific inhibitor of tyrosine-specific protein kinasesJ. Biol. Chem.262(1)5592-5595(1987) 3.Gu, Y., Zhu, C.-F., Iwamoto, H., et al.Genistein inhibits invasive potential of human hepatocellular carcinoma by altering cell cycle, apoptosis, and angiogenesisWorld J. Gastroenterol.11(41)6512-6517(2005) 4.Newbold, R.R., Banks, E.P., Bullock, B., et al.Uterine adenocarcinoma in mice treated neonatally with genisteinCancer Res.614325-4328(2001) 5.Pummoung, S., Werawatganon, D., Klaikeaw, N., et al.Genistein-attenuated hepatic steatosis and inflammation in nonalcoholic steatohepatitis with bilateral ovariectomized ratsPharmacogn. Mag.14(55)20-24(2018) 6.Guo, J., Xu, X., Rasheed, T.K., et al.Genistein interferes with SDF-1- and HIV-mediated actin dynamics and inhibits HIV infection of resting CD4 T cellsRetrovirology1062(2013)

动态评分

0.0

没有评分数据
没有评价数据
一键回到顶部
展开 收缩
安捷凯在线客服