A fungal metabolite with enzyme inhibitory and fungicidal activities
Ilicicolin F is a fungal metabolite that has been found in Fusarium and has enzyme inhibitory and fungicidal activities.1,2,3 It inhibits T. vivax alternative oxidase and E. coli cytochrome bo ubiquinol oxidase (IC50s = 0.43 and 0.37 µM, respectively) but not E. coli cytochrome bd ubiquinol oxidase (IC50 = 85 µM).2 Ilicicolin F is active against the phytopathogenic fungi P. infestans, P. viticola, M. grisea, and S. nodorum when used at a concentration of 500 mg/L.3
1.Ellestad, G.A., Evans, R.H., Jr., and Kunstmann, M.P.Some new terpenoid metabolites from an unidentified fusarium speciesTetrahedron25(6)1323-1334(1969) 2.Mogi, T., Ui, H., Shiomi, K., et al.Antibiotics LL-Z1272 identified as novel inhibitors discriminating bacterial and mitochondrial quinol oxidasesBiochim. Biophys. Acta1787(2)129-133(2009) 3.Bal-Tembe, S., Kundu, S., Roy, K., et al.Activity of the ilicicolins against plant pathogenic fungiPestic. Sci.55(6)645-647(1999)
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