IMS 2186
An anti-choroidal neovascularization agent
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
-
包装价格促销价数量
-
5mg￥1212.00970.00- +
-
10mg￥1787.001430.00- +
-
25mg￥3587.002870.00- +
- 货号: ajcx22656
- CAS: 1031206-36-6
- 别名:
- 分子式: C18H16O4
- 分子量: 296.3
- 纯度: ＞98%
- 溶解度: DMSO: 5 mg/ml,Ethanol: 1 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
IMS 2186 is an anti-choroidal neovascularization agent.1 It inhibits proliferation of NIH3T3 mouse and IMR-90 human fibroblasts (IC50s = 0.5-3 µM), as well as in a panel of eight human cancer cell lines, including ovarian, lung, colon, and pancreatic cancer cells (IC50s = 0.3-3 µM). IMS 2186 (10 µM) decreases migration of THP-1 macrophages in wound healing and chamber assays. Subcutaneous administration of IMS 2186 (20 µg/animal) inhibits VEGF-induced blood vessel formation in a MatrigelTM plug assay in mice. It reduces ocular leakage, as well as cellular proliferation and infiltration in a rat model of laser-induced choroidal neovascularization when administered intravitreally at a dose of 100 µg/eye.
1.Falkenstein, I.A., Cheng, L., Wong-Staal, F., et al.Toxicity and intraocular properties of a novel long-acting anti-proliferative and anti-angiogenic compound IMS2186Curr. Eye Res.33(7)599-609(2008)
