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- Indole-3-pyruvic Acid
Indole-3-pyruvic Acid
An endogenous metabolite of tryptophan
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包装价格促销价数量
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250mg￥837.00670.00- +
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500mg￥1587.001270.00- +
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1g￥2687.002150.00- +
- 货号: ajcx22660
- CAS: 392-12-1
- 别名: 吲哚-3-丙酮酸
- 分子式: C11H9NO3
- 分子量: 203.2
- 纯度: ＞98%
- 溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
Indole-3-pyruvic acid is an endogenous metabolite of tryptophan and intermediate in the biosynthesis of the major auxin hormone, indole-3-acetic acid , in plants.[1][2][3]?Indole-3-pyruvic acid (50 and 250 µM) activates the aryl hydrocarbon receptor (AhR) in a reporter assay.[1]??It reduces UVB-induced cytotoxicity and the levels of COX-2 in HaCaT keratinocytes.4 Topical administration of indole-3-pyruvic acid (100 µmol) reduces the severity of UVB-induced damage in mouse skin. Dietary administration of indole-3-pyruvic acid (0.1%) reduces diarrhea, colonic inflammation, and the colonic expression of Il1b, Ifng, Tnfa, and Il12b in a mouse model of T cell-mediated colitis.[1]??It increases the time spent in the open arms of the elevated plus maze in mice when administered at a dose of 100 mg/kg.[2]??It also reverses the anxiogenic effect of caffeine and 3-hydroxy kynurenine, but not pentylenetetrazole or phenylethylamine, in the elevated plus maze in mice.
Reference:
[1].Aoki, R., Aoki-Yoshida, A., Suzuki, C., et al.Indole-3-pyruvic acid, an aryl hydrocarbon receptor activator, suppresses experimental colitis in miceJ. Immunol.201(12)3683-3693(2018)
[2].Lapin, I.P., and Politi, V.Anxiolytic effect of indole-3-pyruvic acid (IPA) in micePharmacol. Res.28(2)129-134(1993)
[3].Mashiguchi, K., Tanaka, K., Sakai, T., et al.The main auxin biosynthesis pathway in ArabidopsisProc. Natl. Acad. Sci. USA108(45)18512-18517(2011)
[4].Aoki, R., Aoki-Yoshida, A., Suzuki, C., et al.Protective effect of indole-3-pyruvate against ultraviolet b-induced damage to cultured HaCaT keratinocytes and the skin of hairless micePLoS One9(5)e96804(2014)
