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JWH 200 7-hydroxyindole metabolite

A neuropeptide with diverse biological activities

原价
¥1962-7187
价格
1570-5750
JWH 200 7-hydroxyindole metabolite的二维码

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Background

JWH 200 is an aminoalkylindole that acts as a cannabinoid (CB) receptor agonist, binding the CB1 receptor with high-affinity (IC50 = 7.8-42 nM).1,2 JWH 200 is one of several synthetic CBs which have been included in smoking mixtures.3 JWH 200 7-hydroxyindole metabolite is expected to be a urinary metabolite of JWH 200 based on the metabolism of the closely related JWH 015 and JWH 018.4,5



1.Eissenstat, M.A., Bell, M.R., D'Ambra, T.E., et al.Aminoalkylindoles: Structure-activity relationships of novel cannabinoid mimeticsJournal of Medicinal Chemistry383094-3105(1995) 2.Huffman, J.W., Mabon, R., Wu, M.J., et al.3-indolyl-1-naphthylmethanes: New cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB1 cannabinoid receptorBioorganic & Medicinal Chemistry11539-549(2003) 3.Kikura-Hanajiri, R., Uchiyama, N., and Goda, Y.Survey of current trends in the abuse of psychotropic substances and plants in JapanLeg. Med. (Tokyo)13(3)109-115(2011) 4.Zhang, Q., Ma, P., Cole, R.B., et al.Identification of in vitro metabolites of JWH-015, an aminoalkylindole agonist for the peripheral cannabinoid receptor (CB2) by HPLC-MS/MSAnalytical and Bioanalytical Chemistry3861345-1355(2006) 5.Sobolevsky, T., Prasolov, I., and Rodchenkov, G.Detection of JWH-018 metabolites in smoking mixture post-administration urineForensic Sci. Int.200(1-3)141-147(2010)

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