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  • L-Valacyclovir-d8 (hydrochloride)
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L-Valacyclovir-d8 (hydrochloride)

An internal standard for the quantification of valacyclovir

原价
¥3000-5662
价格
2400-4530
L-Valacyclovir-d8 (hydrochloride)的二维码

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  • 库存: 现货
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  • 货号: ajcx22858
  • CAS: 1279033-32-7
  • 别名: 盐酸伐昔洛韦 d8 (盐酸盐)
  • 分子式: C13H12D8N6O4.HCl
  • 分子量: 368.8
  • 纯度: >98%
  • 溶解度: DMF: 10 mg/ml,DMSO: 3 mg/ml,Ethanol: Insolule,PBS (pH 7.2): 10 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

L-Valacyclovir-d8 is intended for use as an internal standard for the quantification of L-valacyclovir by GC- or LC-MS. L-Valacyclovir is an L-valyl prodrug form of the antiviral guanosine analog acyclovir . L-Valacyclovir inhibits herpes simplex virus type 1 (HSV-1) replication (IC50 = 0.84 µM in Vero cells).1 It is more potent than the stereoisomer D-valacyclovir but less potent than acyclovir in vitro, however, it is rapidly converted to acyclovir in vivo.2 Formulations containing L-valacyclovir have been used in the treatment of HSV-1 infections.



1.Beauchamp, L.M., Orr, G.F., de Miranda, P., et al.Amino acid ester prodrugs of acyclovirAntivir. Chem. Chemother.3(3)157-164(1992) 2.Beutner, K.R.Valacyclovir: A review of its antiviral activity, pharmacokinetic properties, and clinical efficacyAntiviral Res.28(4)281-290(1995)

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