A fungal metabolite
Massarigenin C is a fungal metabolite that has been found in M. flavorosea and has enzyme inhibitory activities.1,2 Massarigenin C inhibits neuraminidase in vitro (IC50 = 4.15 µM).2 It is also an inhibitor of yeast α-glucosidase (IC50 = 1.25 mM).1 It reduces the postprandial peak in blood glucose levels in an oral sucrose tolerance test in normo- and hyperglycemic mice when administered at doses of 3.2, 10, and 31.6 mg/kg.
1.Verastegui-Oma?a, B., Rebollar-Ramos, D., Pérez-Vásquez, A., et al.α-Glucosidase inhibitors from Malbranchea flavoroseJ. Nat. Prod.80(1)190-195(2017) 2.Zhang, G.F., Han, W.B., Cui, J.T., et al.Neuraminidase inhibitory polyketides from the marine-derived fungus Phoma herbaruPlanta Med.78(1)76-78(2012)
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