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A neuropeptide with diverse biological activities
Mca-PLGL-Dap(Dnp)-AR-NH2 is a fluorogenic peptide substrate for matrix metalloproteinases (MMPs).1 Upon cleavage by an MMP, 7-methoxycoumarin-4-acetyl (Mca) is released and its fluorescence can be used to quantify MMP activity. Mca has excitation and emission maxima of 328 and 420 nm, respectively.
1.Edkins, T.J., Alhadeff, J.A., Kwok, V., et al.Development and validation of novel enzyme activity methods to assess inhibition of matrix metalloproteinases (MMPs) in human serum by antibodies against enzyme therapeuticsJ. Pharm. Biomed. Anal.70408-414(2012)
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