Mca-YVADAP-K(Dnp)-OH (trifluoroacetate salt)

A neuropeptide with diverse biological activities

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500ug

￥2587.00

2070.00

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货号: ajcx22892
CAS: N/A
别名: Caspase-1 Fluorogenic Substrate V, Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(DNP)-OH, Mca-YVADAP-Lys(Dnp)-OH, (7-Methoxycoumarin-4-yl)acetyl-YVADAPK(2,4-dinitrophenyl)-OH
分子式: C53H64N10O19.XCF3COOH
分子量: 1145.1
纯度: >98%
溶解度: Water: 1 mg/ml
储存: Store at -20°C
库存: 现货

Background

Mca-YVADAP-K(Dnp)-OH is a substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2).^1,2 Upon cleavage by caspase-1 or ACE2, 7-methoxycoumarin-4-acetyl (Mca) is released and its fluorescence can be used to quantify enzyme activity. Mca displays excitation/emission maxima of 328/420 nm, respectively.

1.Vickers, C., Hales, P., Kaushik, V., et al.Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidaseJ. Biol. Chem.277(17)14838-14843(2002) 2.Enari, M., Talanian, R.V., Wong, W.W., et al.Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosisNature380(6576)723-726(1996)