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- Melperone-d4 (hydrochloride)
Melperone-d4 (hydrochloride)
An internal standard for the quantification of melperone
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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500ug￥1150.00920.00- +
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1mg￥2162.001730.00- +
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5mg￥7900.006320.00- +
- 货号: ajcx22900
- CAS: 1219798-80-7
- 别名: 盐酸美哌隆-D4/盐酸甲哌酮-D4
- 分子式: C16H18D4FNO.HCl
- 分子量: 303.8
- 纯度: ＞98%
- 溶解度: DMF: soluble,DMSO: soluble,Ethanol: soluble,PBS (pH 7.2): soluble
- 储存: Store at -20°C
- 库存: 现货
Background
Melperone-d4 is intended for use as an internal standard for the quantification of melperone by GC- or LC-MS. Melperone is an atypical antipsychotic.1 It binds to α1- and α2-adrenergic and dopamine D2 receptors (Kds = 180, 150, and 180 nM, respectively), as well as the serotonin (5-HT) receptor subtype 5-HT2A (Kd = 102 nM). It is selective for these receptors over histamine H1, muscarinic, 5-HT1A, 5-HT1D, and 5-HT2C receptors (Kds = 580, >10,000, 2,200, 3,400, and 2,100 nM, respectively). Melperone (2 mg/kg per day) increases basal, but not amphetamine-induced, extracellular dopamine levels in the rat nucleus accumbens.2
1.Richelson, E., and Souder, T.Binding of antipsychotic drugs to human brain receptors: Focus on newer generation compoundsLife Sci.68(1)29-39(2000) 2.Ichikawa, J., and Meltzer, H.Y.The effect of chronic atypical antipsychotic drugs and haloperidol on amphetamine-induced dopamine release in vivoBrain Res.574(1-2)98-104(1992)
