An insecticidal antibiotic
Milbemectin is an insecticide used primarily to control mites.1 Milbemectin is a mixture of milbemycin A3 and milbemycin A4 that has acaricidal and nematocidal activity against adult spider mites, spider mite eggs, and C. elegans with IC50 values of 5.3, 41.1, and 9.5 µg/ml, respectively.2 It acts as an allosteric agonist of the Drosophila RDL GABA receptor.3 It is also effective against the pinewood nematode, B. xylophilus with an LC20 of 0.0781 mg/liter.4
1.Macrocyclic InsecticidesMetabolic Pathways of Agrochemicals, Part 2: Insecticides and Fungicides (Metabolic Pathways)95-98(1999) 2.Yang, L.Y., Wang, J.D., Zhang, J., et al.New nemadectin congeners with acaricidal and nematocidal activity from Streptomyces microflavus neau3 Y-3Bioorg. Med. Chem. Lett.23(20)5710-5713(2013) 3.Nakao, T., Banba, S., and Hirase, K.Comparison between the modes of action of novel meta-diamide and macrocyclic lactone insecticides on the RDL GABA receptor.Pestic. Biochem. Physiol.120101-108(2015) 4.Bi, Z., Gong, Y., Huang, X., et al.Efficacy of four nematicides against the reproduction and development of pinewood nematode, Bursaphelenchus xylophilus.J. Nematol.47(2)126-132(2015)
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