m-Methoxybenzamide
A PARP inhibitor
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包装价格促销价数量
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5g￥1012.00810.00- +
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10g￥1925.001540.00- +
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25g￥4525.003620.00- +
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- 货号: ajcx22974
- CAS: 5813-86-5
- 别名: 3-甲氧基苯甲酰胺,3-MBA
- 分子式: C8H9NO2
- 分子量: 151.2
- 纯度: ＞98%
- 溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.50 mg/ml,Ethanol: 1 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
m-Methoxybenzamide is an inhibitor of poly(ADP-ribose) polymerase (PARP; Ki = <2 µM).1 It also inhibits human placental ADP ribosyl transferase activity by 93% when used at a concentration of 100 µM.2 m-Methoxybenzamide (100, 200, and 300 mg/kg) increases the pain threshold in the paw pinch test in rats.3
1.Purnell, M.R., and Whish, W.J.Novel inhibitors of poly(ADP-ribose) synthetaseBiochem. J.185(3)775-777(1980) 2.Burtscher, H.J., Auer, B., Klocker, H., et al.Isolation of ADP-ribosyltransferase by affinity chromatographyAnal. Biochem.152(2)285-290(1986) 3.Sanders, R., Dill, R.E., Dorris, R.L., et al.Analgesic effects of 3-methoxybenzamide in ratsJ. Pharm. Pharmacol.41(4)268-269(1989)
