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- MMK1 (trifluoroacetate salt)
MMK1 (trifluoroacetate salt)
A neuropeptide with diverse biological activities
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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1mg￥1150.00920.00- +
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5mg￥4500.003600.00- +
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10mg￥6775.005420.00- +
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25mg￥12587.0010070.00- +
- 货号: ajcx22978
- CAS: N/A
- 别名: LESIFRSLLFRVM, Leu-Glu-Ser-Ile-Phe-Arg-Ser-Leu-Leu-Phe-Arg-Val-Met
- 分子式: C75H123N19O18S .XCF3COOH
- 分子量: 1611
- 纯度: ＞98%
- 溶解度: Methanol: soluble
- 储存: Store at -20°C
- 库存: 现货
Background
MMK1 is an agonist of formyl peptide receptor 2 (FPR2), which was previously known as formyl peptide receptor-like 1 (FPRL1).1 MMK1 induces calcium flux in CHO cells expressing human FPR2 and Gα16 (EC50 = <2 nM) but not in CHO cells expressing Gα16 alone or in combination with FPR1 (EC50s = >10,000 nM for both). It induces chemotaxis of isolated human peripheral blood monocytes and neutrophils in a concentration-dependent manner.2 MMK1 (10 µM) increases production of the proinflammatory cytokines IL-1β and IL-6 in isolated human monocytes. Intracerebroventricular administration of MMK1 (100 pmol/mouse) increases the percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity.3
1.Klein, C., Paul, J.I., Sauvé, K., et al.Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeastNat. Biotechnol.16(13)1334-1337(1998) 2.Hu, J.Y., Le, Y., Gong, W., et al.Synthetic peptide MMK-1 is a highly specific chemotactic agonist for leukocyte FPRL1J. Leukoc. Biol.70(1)155-161(2001) 3.Zhao, H., Sonada, S., Yoshikawa, A., et al.Rubimetide, humanin, and MMK1 exert anxiolytic-like activities via the formyl peptide receptor 2 in mice followed by the successive activation of DP1, A2A, and GABAA receptorsPeptides8316-20(2016)
