A caged neurotransmitter used with photolysis
MNI-caged-L-glutamate is a form of glutamate linked to a 4-methoxy-7-nitroindolinyl (MNI) photoprotecting group that is pharmacologically inactive at neuronal glutamate receptors (up to mM concentrations).1 Upon exposure to light (300 - 380 nm excitation), L-glutamate is cleaved of MNI and released within submicroseconds.1 This compound can be used to investigate the mechanisms of fast synaptic glutamate receptors in situ.
1.Canepari, M., Nelson, L., Papageorgiou, G., et al.Photochemical and pharmacological evaluation of 7-nitroindolinyl-and 4-methoxy-7-nitroindolinyl-amino acids as novel, fast caged neurotransmittersJ.Neurosci.Methods112(1)29-42(2001)
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