A synthetic glucocorticoid with anti-inflammatory and anti-allergic activities
Mometasone is a synthetic glucocorticoid with anti-inflammatory and anti-allergic activities.1,2,3 In vivo, mometasone (3 mg/kg) reduces pulmonary edema and neutrophil infiltration in a mouse model of chlorine-induced chemical lung injury.1 Intranasal administration of mometasone (0.2 µg/animal) reduces nose-rubbing behavior, sneezing, and nasal mucosal levels of IL-4 in a mouse model of allergic rhinitis.2 Mometasone also reduces nasal mucosal epithelial destruction, fibrosis, and cilia loss in a rat model of rhinitis medicamentosa induced by oxymetazoline .
1.Kitlevsen, D.K., Povlsen, G.K., Berezin, V., et al.NCAM-induced intracellular signaling revisitedJ. Neurosci. Res.86(4)727-743(2008) 2.Williams, E.J., Furness, J., Walsh, F.S., et al.Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherinNeuron.13(3)583-594(1994) 3.Van Acker, H.H., Van Acker, Z.P., Versteven, M., et al.CD56 homodimerization and participation in anti-tumor immune effector cell functioning: A role for interleukin-15Cancers (Basel)11(7)1029(2019)
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