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- Cyclooxygenase (COX)
- Nabumetone-d3
Nabumetone-d3
An internal standard for the quantification of nabumetone
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包装价格促销价数量
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1mg￥4075.003260.00- +
- 货号: ajcx23040
- CAS: 1216770-08-9
- 别名: 萘丁美酮-D3,BRL14777-d3
- 分子式: C15H13D3O2
- 分子量: 231.3
- 纯度: ＞98%
- 溶解度: Chloroform: slightly soluble,Ethyl Acetate: slightly soluble
- 储存: Store at -20°C
- 库存: 现货
Background
Nabumetone-d3 is intended for use as an internal standard for the quantification of nabumetone by GC- or LC-MS. Nabumetone is a non-steroidal anti-inflammatory drug (NSAID) and a prodrug form of 6-methoxy naphthalene acetic acid .1 Nabumetone (5-45 mg/kg) reduces carrageenan-induced edema in rats, as well as UV-induced erythema in guinea pigs (ED50 = 11 mg/kg).2 It reduces phenyl-p-quinone-induced writhing in mice (ED50 = 152 mg/kg). Nabumetone (50, 100, and 200 mg/kg) reduces endotoxin-induced pyresis in rabbits.
1.Cryer, B., and Feldman, M.Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugsAm. J. Med.104(5)413-421(1998) 2.Boyle, E.A., Freeman, P.C., Mangan, F.R., et al.Nabumetone (BRL 14777, 4-[6-methoxy-2-naphthyl]-butan-2-one): a new anti-inflammatory agentJ. Pharm. Pharmacol.34(9)562-569(1982)
