Nalanthalide

A fungal metabolite with potassium channel inhibitory and antiviral activities

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库存: 现货

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1mg

￥4612.00

3690.00

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货号: ajcx23054
CAS: 145603-76-5
别名: (–)-Nalanthalide
分子式: C30H44O5
分子量: 484.7
纯度: >98%
溶解度: Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
储存: Store at -20°C
库存: 现货

Background

Nalanthalide is a diterpenoid pyrone fungal metabolite that has been found in Nalanthamala and has potassium channel inhibitory and antiviral activities.¹ It inhibits binding of the potassium channel inhibitor charybdotoxin to Jurkat cell membranes (IC₅₀ = 3 µM) and inhibits rubidium efflux from CHO cells expressing the voltage-gated potassium (K_v) channel K_v1.3 (IC₅₀ = 3.9 µM). Nalanthalide depolarizes T cells in vitro with an EC₅₀ value of 500 nM. It also inhibits HIV-1 integrase activity with IC₅₀ values of 10 and 25 µM in coupled and strand transfer assays, respectively.²

1.Goetz, M.A., Zink, D.L., Dezeny, G., et al.Diterpenoid pyrones, novel blockers of the voltage-gated potassium channel Kv1.3 from fungal fermentationsTetrahedron Lett.42(7)1255-1257(2001) 2.Singh, S.B., Jayasuriya, H., Dewey, R., et al.Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolitesJ. Ind. Microbiol. Biotechnol.30(12)721-731(2003)