现货大促销,价格低至8折起,量大更优惠,详细咨询客服
全部分类
全部分类
  • Nalanthalide
Nalanthalide的可视化放大

Nalanthalide

A fungal metabolite with potassium channel inhibitory and antiviral activities

原价
¥4612-4612
价格
3690-3690
Nalanthalide的二维码

所有产品仅用于科学研究,我们不为任何个人用途提供产品和服务

询价有惊喜,量大更优惠 点击这里给我发消息

  • 库存: 现货
可选包装 >>>
首页
  • 货号: ajcx23054
  • CAS: 145603-76-5
  • 别名: (–)-Nalanthalide
  • 分子式: C30H44O5
  • 分子量: 484.7
  • 纯度: >98%
  • 溶解度: Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
  • 储存: Store at -20°C
  • 库存: 现货

Background

Nalanthalide is a diterpenoid pyrone fungal metabolite that has been found in Nalanthamala and has potassium channel inhibitory and antiviral activities.1 It inhibits binding of the potassium channel inhibitor charybdotoxin to Jurkat cell membranes (IC50 = 3 µM) and inhibits rubidium efflux from CHO cells expressing the voltage-gated potassium (Kv) channel Kv1.3 (IC50 = 3.9 µM). Nalanthalide depolarizes T cells in vitro with an EC50 value of 500 nM. It also inhibits HIV-1 integrase activity with IC50 values of 10 and 25 µM in coupled and strand transfer assays, respectively.2



1.Goetz, M.A., Zink, D.L., Dezeny, G., et al.Diterpenoid pyrones, novel blockers of the voltage-gated potassium channel Kv1.3 from fungal fermentationsTetrahedron Lett.42(7)1255-1257(2001) 2.Singh, S.B., Jayasuriya, H., Dewey, R., et al.Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolitesJ. Ind. Microbiol. Biotechnol.30(12)721-731(2003)

动态评分

0.0

没有评分数据
没有评价数据
一键回到顶部
展开 收缩
安捷凯在线客服