N-desmethyl Rosuvastatin (sodium salt hydrate)
An active metabolite of rosuvastatin
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包装价格促销价数量
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500ug￥2587.002070.00- +
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1mg￥4875.003900.00- +
- 货号: ajcx23076
- CAS: N/A
- 别名:
- 分子式: C21H24FN3O6S.2Na [H2O]
- 分子量: 529.5
- 纯度: ＞98%
- 溶解度: DMSO: Slightly, heated,Methanol: slightly soluble,Water: slightly soluble
- 储存: Store at -20°C
- 库存: 现货
Background
N-desmethyl Rosuvastatin is an active metabolite of the HMG-CoA reductase inhibitor rosuvastatin .1,2 N-desmethyl Rosuvastatin is formed when rosuvastatin undergoes demethylation, primarily by the cytochrome P450 (CYP) isoform CYP2C9 and to a lesser extent by CYP2C19 and CYP3A4.1
1.Macwan, J.S., Ionita, I.A., and Akhlaghi, F.A simple assay for the simultaneous determination of rosuvastatin acid, rosuvastatin-5S-lactone, and N-desmethyl rosuvastatin in human plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS)Anal. Bioanal. Chem.402(3)1217-1227(2012) 2.Bai, X., Wang, X.P., He, G.D., et al.Simultaneous determination of rosuvastatin, rosuvastatin-5 S-lactone, and N-desmethyl rosuvastatin in human plasma by UPLC-MS/MS and its application to clinical studyDrug Res. (Stuttg.)68(6)328-334(2018)
