Nevirapine-d4

An internal standard for the quantification of nevirapine

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库存: 现货

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数量
1mg

￥5100.00

4080.00

- +
5mg

￥15187.00

12150.00

- +

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货号: ajcx23096
CAS: 1051418-95-1
别名: 奈韦拉平 D4
分子式: C15H10D4N4O
分子量: 270.3
纯度: >98%
溶解度: DMF: 5 mg/ml,DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml,DMSO: 2.5 mg/ml
储存: Store at -20°C
库存: 现货

Background

Nevirapine-d₄ is intended for use as an internal standard for the quantification of nevirapine by GC- or LC-MS. Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI).¹ It binds to HIV-1 reverse transcriptase and inhibits RNA plus-strand initiation (IC₅₀ = 0.45 μM). Nevirapine prevents seroconversion and viremia in a chimpanzee model of HIV-1 infection.² Formulations containing nevirapine have been used in combination therapy for the treatment of HIV-1 infection.

1.Grobler, J.A., Dornadula, G., Rice, M.R., et al.HIV-1 reverse transcriptase plus-strand initiation exhibits preferential sensitivity to non-nucleoside reverse transcriptase inhibitors in vitroJ. Biol. Chem.282(11)8005-8010(2007) 2.Grob, P.M., Cao, Y., Muchmore, E., et al.Prophylaxis against HIV-1 infection in chimpanzees by nevirapine, a nonnucleoside inhibitor of reverse transcriptaseNat. Med.3(6)665-670(1997)