Norfloxacin-d5

An internal standard for the quantification of norfloxacin

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
1mg

￥675.00

540.00

- +
5mg

￥3050.00

2440.00

- +
10mg

￥4750.00

3800.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajcx23136
CAS: 1015856-57-1
别名: 诺氟沙星 d5
分子式: C16H13D5FN3O3
分子量: 324.4
纯度: >98%
溶解度: Chloroform: slightly,DMSO: slightly, heated
储存: Store at -20°C, protect from light
库存: 现货

Background

Norfloxacin-d₅ is intended for use as an internal standard for the quantification of norfloxacin by GC- or LC-MS. Norfloxacin is a fluoroquinolone antibiotic that inhibits the growth of Gram-positive and Gram-negative bacteria (MICs = 4 and 1 μg/ml for S. aureus and P. aeruginosa, respectively).¹ It also inhibits the growth S. pseudintermedius, S. aureus, E. coli, Pasturella, and S. canis isolates from dogs (mean MIC₅₀s = 0.25, 1, 0.03, 1, and 1 μg/ml, respectively).² Topical administration of norfloxacin (0.1% v/v) reduces corneal ulcer size in a rabbit model of P. aeruginosa corneal infection. It also prevents encrusted cystitis in bladder and increases survival in a rat model of Corynebacterium group D2 infection when administered at a dose of 80 mg/kg per day.³ Formulations containing norfloxacin have been used to treat urinary tract and gynecological infections.

1.Darrell, R.W., Modak, S.M., and Fox, C.L., Jr.Norfloxacin and silver norfloxacin in the treatment of Pseudomonas corneal ulcer in the rabbit.Trans. Am. Opthalmol. Soc.8275-91(1984) 2.Awji, E.G., Damte, D., Lee, S.-J., et al.The in vitro activity of 15 antimicrobial agents against bacterial isolates from dogsJ. Vet. Med. Sci.74(8)1091-1094(2012) 3.Soriano, F., Rodriguez-Tudela, J.L., Castilla, C., et al.Treatment of encrusted cystitis caused by Corynebacterium group D2 with norfloxacin, ciprofloxacin, and teicoplanin in an experimental model in ratsAntimicrob. Agents Chemother.35(12)2587-2590(1991)