An internal standard for the quantification of octanoyl-L-carnitine
Octanoyl-L-carnitine-d3 is intended for use as an internal standard for the quantification of octanoyl-L-carnitine by GC- or LC-MS. Octanoyl-L-carnitine is a medium-chain acylcarnitine and the physiologically active form of octanoyl-DL-carnitine .1 Plasma levels of octanoyl-L-carnitine are elevated in patients with end-stage renal disease on continuous ambulatory peritoneal dialysis (PD) compared with both patients on automated PD and healthy individuals.2 Octanoyl-L-carnitine does not undergo hydrolysis in the blood or during sample preparation when used as a standard for the quantification of octanoylcarnitine.1
1.Chace, D.H., DiPerna, J.C., Adam, B.W., et al.Errors caused by the use of D,L-octanoylcarnitine for blood-spot calibratorsClin. Chem.47(4)758-760(2001) 2.Di Liberato, L., Arduini, A., Rossi, C., et al.L-Carnitine status in end-stage renal disease patients on automated peritoneal dialysisJ. Nephrol.27(6)699-706(2014)
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