Palmitoyl Ethanolamide-d4

An internal standard for the quantification of palmitoyl ethanolamide

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100ug

￥575.00

460.00

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500ug

￥2600.00

2080.00

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1mg

￥4587.00

3670.00

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5mg

￥19925.00

15940.00

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货号: ajcx23222
CAS: 946524-34-1
别名: Palmidrol-d4; Loramine P 256-d4
分子式: C18H33D4NO2
分子量: 303.5
纯度: >98%
溶解度: DMF: 10 mg/ml,DMSO: 5 mg/ml,Ethanol: 2 mg/ml,Ethanol:PBS (pH 7.2) (1:10): .01 mg/ml
储存: Store at -20°C
库存: 现货

Background

Palmitoyl ethanolamide-d₄ (PEA-d₄) contains four deuterium atoms at the 1,1', 2, and 2' positions. It is intended for use as an internal standard for the quantification of PEA by GC- or LC-mass spectrometry. Palmitoyl ethanolamide (PEA) is an endogenous cannabinoid found in brain, liver, and other mammalian tissues.¹ PEA has also been isolated from egg yolk, and found to have anti-anaphylactic and anti-inflammatory activity in vitro.² PEA is an endocannabinoid which has been shown to significantly elevate cAMP in cells expressing CB₂ receptors. However, its affinity for CB₂ receptors is relatively low, at about 10 µM. CB₁ receptors have no appreciable affinity for PEA.³

1.Bachur, N.R., Masek, K., Melmon, K.L., et al.Fatty acid amides of ethanolamine in mammalian tissuesJ. Biol. Chem.2401019-1024(1965) 2.Ganley, O.H., Graessle, O.E., Robinson, H.J., et al.Anti-inflammatory activity of compounds obtained from egg yolk, peanut oil, and soybean lecithinJournal of Laboratory and Clinical Medicine51709-714(1958) 3.Devane, W.A., Hanus, L., Breuer, A., et al.Isolation and structure of a brain constituent that binds to the cannabinoid receptorScience258(5090)1946-1949(1992)