现货大促销,价格低至8折起,量大更优惠,详细咨询客服
全部分类
全部分类
  • Paraxanthine-d6
Paraxanthine-d6的可视化放大

Paraxanthine-d6

An internal standard for the quantification of paraxanthine

原价
¥2037-12075
价格
1630-9660
Paraxanthine-d6的二维码

所有产品仅用于科学研究,我们不为任何个人用途提供产品和服务

询价有惊喜,量大更优惠 点击这里给我发消息

  • 库存: 现货
可选包装 >>>
首页
  • 货号: ajcx23238
  • CAS: 117490-41-2
  • 别名: 1,7-Dimethylxanthine-d6
  • 分子式: C7H2D6N4O2
  • 分子量: 186.2
  • 纯度: >98%
  • 溶解度: DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

Paraxanthine-d6 is intended for use as an internal standard for the quantification of paraxanthine by GC- or LC-MS. Paraxanthine is an active metabolite of caffeine .1 It is formed via N3-demethylation of caffeine by the cytochrome P450 (CYP) isoform CYP1A2. Paraxanthine is an adenosine A1 and A2 receptor antagonist (Kis = 35 and 22 µM, respectively).2 In vivo, paraxanthine (30 mg/kg) increases striatal cGMP and extracellular striatal dopamine levels and locomotor activity, as well as inhibits motor depression induced by the adenosine A1 agonist CPA or the adenosine A2 receptor agonist CGS 21680 in rats not habituated to caffeine.3 It also promotes wakefulness and increases locomotor activity and core temperature in narcoleptic transgenic mice without increasing behavioral anxiety.4



1.Tassaneeyakul, W., Birkett, D.J., McManus, M.E., et al.Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoformsBiochem. Pharmacol.47(10)1767-1776(1994) 2.Chou, C.-C., and Vickroy, T.W.Antagonism of adenosine receptors by caffeine and caffeine metabolites in equine forebrain tissuesAm. J. Vet. Res.64(2)216-224(2003) 3.Orrú, M., Guitart, X., Karcz-Kubicha, M., et al.Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humansNeuropharmacology67476-484(2013) 4.Okuro, M., Fujiki, N., Kotorii, N., et al.Effects of paraxanthine and caffeine on sleep, locomotor activity, and body temperature in orexin/ataxin-3 transgenic narcoleptic miceSleep33(7)930-942(2010)

动态评分

0.0

没有评分数据
没有评价数据
一键回到顶部
展开 收缩
安捷凯在线客服